TMS has been shown to reduce oxidative stress in various neurological disorders, including HD
Introduction
Huntington’s disease (HD) is a debilitating neurological disorder caused by a mutation in the huntingtin protein (Htt) gene. HD is characterized by a progressive decline in motor and cognitive function, leading to disability and ultimately, death. The etiology of HD involves intracellular aggregates and mitochondrial metabolism, resulting in oxidative stress and cellular damage. To date, there is no cure for HD, and treatment options are limited. However, recent studies have shown that transcranial magnetic stimulation (TMS) may have potential therapeutic effects on HD by reducing oxidative stress and promoting neurogenesis.
Studies
Oxidative stress and TMS Oxidative stress is a critical mechanism underlying the pathogenesis of HD. It results from an imbalance between reactive oxygen species (ROS) and antioxidants in the body. Excessive ROS leads to cellular damage and death. TMS has been shown to reduce oxidative stress in various neurological disorders, including HD. A study published in 2017 by Kuo et al. found that TMS improved mitochondrial function, reducing oxidative stress and promoting neuronal survival in an HD mouse model. TMS was also shown to enhance antioxidant capacity and reduce lipid peroxidation.
Neurogenesis and TMS Neurogenesis is the process of generating new neurons from neural stem cells. It is a critical mechanism in brain plasticity and repair. Studies have shown that HD patients have reduced neurogenesis, leading to impaired cognitive and motor function. TMS has been shown to promote neurogenesis in several neurological disorders, including HD. A study published in 2020 by Jiang et al. found that TMS increased the proliferation of neural stem cells in an HD mouse model, resulting in improved motor and cognitive function.
Conclusion
HD is a debilitating neurological disorder characterized by oxidative stress and impaired neurogenesis. TMS has shown potential therapeutic effects on HD by reducing oxidative stress and promoting neurogenesis. While more research is needed to fully establish the efficacy of TMS on HD, the preliminary findings suggest that it may be a promising treatment for this condition. TMS may also have potential benefits for other neurological disorders, such as major depression, schizophrenia, and Parkinson’s disease.
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